Lacidipine

Lacidipine is a group of type calcium channel blocker drug. Lacidipine works by relaxing the heart muscle and blood vessels.

Indications:

To treat high blood pressure (hypertension).

Dosage:

The initial dose: 2 mg by mouth (orally), 1 times daily

May be increased to 4 mg, if necessary to 6 mg by mouth (orally), 1 time a day after at least 3-4 weeks away.

Side Effects:

CV effects (decreased cardiac function, hypotension, heart failure is getting worse, edema, skin redness, bradycardia), GI effects (constipation); CNS effects (headache, dizziness).

HR regulate calcium antagonists (Diltiazem, Gallopamil & verapamil); AV dissociation, AV block, bradycardia, and sinus stem dysfunction.

Short-acting dihydropyridine agents should be avoided because it has the potential to increase the risk of adverse cardiac events.

Special Instructions:

Berkontraindikasi with patients who clearly have decompensated HR, although vasoselective dihydropyridine (eg Amlodipine and Felodipine) can be accepted by patients with reduced LV solution.

HR berkontraindikasi regulating calcium antagonists in patients with bradycardia, sinus stem dysfunction, and AV nodal block.