Epoprostenol

:

Epoprostenol is a prostaglandin drug group. This drug works by widening blood vessels and increasing blood to the lungs, thereby reducing the workload of the heart.

Indications:

To treat high blood pressure in blood vessels associated with the lungs.

Dosage:

Hard to determine the range of doses that can be tolerated dose: 2 ng / kg / minute to continue through the blood vessels (intra venous).

Increase with increase of 2 ng / kg / min every 15 minutes or longer until the effect of the dose limit is reached.

Initial infusion continued ongoing: 4 ng / kg / min less than the maximum tolerated infusion set during the high dose included.

If the maximum tolerated infusion of less than 5 ng / kg / min, continuous infusion value should be around half of the value of the maximum tolerated infusion.

May adjust the dose based on symptoms and pH may be increased with the increase of 1-2 ng / kg / min every 15 minutes or longer.

Side Effects:

Dose limiting effects: chest pain, anxiety, dizziness, changes in heart rate, dyspnea, N / V, headache, hypotension, skin redness.

Other effects: muscle aches, sore jaw.

Adverse events related to the delivery system is more serious and associated with pump malfunction, local point of infections, catheter damage and sepsis.

Special Instructions:

Avoid in patients with congestive heart failure (CHF) due to left ventricular systolic dysfunction and in those who develop pulmonary edema during dose delivery.

Give to continue the infusion through the heart vessels (intra venous) through the main vein chateter using ambulatory infusion pumps; during dosing, could be around him.

Termination Epoprostenol denngan suddenly should be avoided because the risk of PH keminculan back.

Haematological monitoring is required and CV.